Dextromethorphan, when misused, is associated with what potential risk?

• A. Cough suppression with no risk
• B. Abuse and dissociative effects
• C. Only mild sedation
• D. No adverse effects

Answer: (B)

Dextromethorphan misuse carries the risk of abuse and dissociative effects. When taken at high, non-approved doses, it acts as an NMDA receptor antagonist, which can produce psychoactive experiences such as dissociation, perceptual distortions, and euphoria. These effects drive misuse and can lead to dependence and withdrawal, alongside other risks like impaired coordination, confusion, nausea, and potential dangerous interactions with alcohol or other drugs. In contrast, statements suggesting only mild sedation or no adverse effects ignore the substantial psychoactive and addictive potential that appears at higher doses.