Which of the following is a common early sign of acetaminophen overdose in a child?

• A. Jaundice
• B. Drowsiness
• C. Nausea and vomiting
• D. All of the above

Answer: (C)

Early acetaminophen toxicity typically shows non-specific symptoms before clear liver distress develops. Nausea and vomiting are the most common and recognizable early signs in children, reflecting the body's initial reaction to the overdose. Jaundice tends to appear later, after significant liver injury has progressed and bilirubin handling is affected. Drowsiness can occur with more serious toxicity, but it’s less consistently seen as the first clue. So, nausea and vomiting best capture the early clinical picture researchers and clinicians look for after an overdose. If overdose is suspected, urgent medical care is essential, as treatment with antidotes is time-sensitive.