Why should aspirin be avoided in children and teenagers with viral infections?

• A. Risk of Reye's syndrome
• B. Risk of asthma
• C. Risk of hearing loss
• D. Risk of tooth decay

Answer: (A)

Giving aspirin to children or teenagers during a viral illness can trigger Reye's syndrome, a rare but serious condition that causes swelling of the brain and liver. The connection between aspirin and this syndrome led to strong recommendations to avoid aspirin for fever or pain in anyone under 19 who has a viral infection. The exact mechanism isn’t fully understood, but aspirin during a viral illness is believed to disrupt mitochondrial function in liver cells, leading to fatty liver and brain edema. For fever or discomfort in kids, safer options are acetaminophen or ibuprofen, used with correct dosing. If a child with a viral illness develops persistent vomiting, confusion, or reduced responsiveness, seek medical care promptly, as these can be signs of Reye's syndrome.